Chicken Florentine Casserole (High Protein Low Calorie Recipe)

Florentine dishes are known for their rich, creamy texture and fresh spinach, and this Creamy Chicken Florentine Casserole brings those classic flavors into an easy, one-pan meal.

It’s decadent yet wholesome, with a creamy garlic-Parmesan sauce that coats tender chicken and wilted spinach for a dish that feels both indulgent and nourishing.

This casserole is perfect for meal prep because it reheats beautifully and pairs well with just about anything—cauliflower rice, zucchini noodles, or even a simple side salad. It’s also a fantastic way to get protein and leafy greens in one delicious meal. If you love creamy, cheesy casseroles but want something low-carb, satisfying, and packed with flavor, this recipe is a must-try!

Why You’ll Love This Chicken Florentine Casserole Recipe

• Rich, creamy, and comforting, but still balanced and healthy
• Packed with protein and nutrient-dense spinach
• Great for meal prep—flavors get even better the next day
• Pairs well with a variety of sides
• One-pan meal that’s easy to make and clean up

Ingredients

• 1 ½ lbs boneless, skinless chicken breasts, cut into strips
• 1 tablespoon olive oil
• ½ teaspoon salt
• ½ teaspoon black pepper
• ½ teaspoon garlic powder
• ½ teaspoon dried basil
• 3 cloves garlic, minced
• 2 cups fresh spinach, chopped
• 1 cup heavy cream
• ½ cup cream cheese, softened
• ½ teaspoon Dijon mustard
• ½ teaspoon red pepper flakes (optional)
• ½ cup shredded mozzarella cheese
• ½ cup grated Parmesan cheese
• ¼ cup almond flour or crushed pork rinds (for topping)
• 2 tablespoons butter, melted

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Instructions

1. Preheat oven to 375°F (190°C) and grease a 9×13-inch baking dish.
2. Heat olive oil in a large skillet over medium heat. Add the chicken strips and season with salt, black pepper, garlic powder, and dried basil. Cook for 4-5 minutes until lightly browned, then transfer to the prepared baking dish.
3. In the same skillet, sauté minced garlic for 30 seconds, then add chopped spinach and cook until just wilted. Remove from heat.
4. In a bowl, whisk together heavy cream, cream cheese, Dijon mustard, and red pepper flakes until smooth. Stir in the sautéed spinach and garlic.
5. Pour the creamy spinach mixture over the chicken in the baking dish. Sprinkle mozzarella and Parmesan cheese evenly over the top.
6. In a small bowl, mix almond flour (or crushed pork rinds) with melted butter and sprinkle over the casserole.
7. Bake uncovered for 20-25 minutes, or until the cheese is melted and bubbly and the topping is golden brown.
8. Let cool slightly before serving.

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Nutritional Info (per serving, serves 6):

Calories: ~350
Protein: ~32g
Carbs: ~6g
Fat: ~22g

Quick Tips for This Chicken Florentine Recipe

• Want even more flavor? Add a splash of white wine to the cream sauce before baking.
• For a richer texture, stir in an extra tablespoon of cream cheese.
• Make it dairy-free by using full-fat coconut milk instead of heavy cream and dairy-free cheese alternatives.
• Serve over cauliflower rice, mashed potatoes, or zucchini noodles for a more filling meal.
• Great for meal prep! Store leftovers in an airtight container for up to 4 days and reheat in the oven or microwave.

PIN & SAVE THIS RECIPE!

A golden, bubbling casserole filled with tender chicken smothered in a creamy garlic-Parmesan sauce, speckled with wilted spinach. The crispy topping adds the perfect crunch, while melted mozzarella creates gooey, irresistible cheese pulls with every bite.